Pathophysiological mechanisms of oropharyngeal dysphagia in amyotrophic lateral sclerosis
نویسندگان
چکیده
منابع مشابه
Pathophysiological mechanisms of oropharyngeal dysphagia in amyotrophic lateral sclerosis.
We investigated the pathophysiological mechanisms of dysphagia in amyotrophic lateral sclerosis. Forty-three patients with sporadic amyotrophic lateral sclerosis were examined by clinical and electrophysiological methods that objectively measured the oropharyngeal phase of voluntarily initiated swallowing, and these results were compared with those obtained from 50 age-matched control subjects....
متن کاملA Case of Amyotrophic Lateral Sclerosis Presented as Oropharyngeal Dysphagia
Amyotrophic lateral sclerosis is a rare disease. It is a fatal neurodegenerative disease characterized by progressive muscular paralysis reflecting degeneration of motor neurons which leads to muscle weakness and muscle wasting. Respiratory failure limits survival to 2-5 years after disease onset. Several clinical manifestations including dysphagia can result in reductions in both the quality o...
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Grundström, E. 2000. On Pathophysiological Mechanisms in Amyotrophic Lateral Sclerosis. Acta Universitatis Upsaliensis, Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 967. 52 pp. Uppsala ISBN 91-554-4838-0. Amyotrophic lateral sclerosis is a fatal, progressive neurodegenerative disease with unknown ethiology. The aim of this study was to increase understanding of ...
متن کاملMechanisms of neurodegeneration in amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis (ALS) is the most common variant of motor neurone disease affecting adults that usually strikes during mid to late life. Its aetiology is still poorly understood, although a major breakthrough came with the discovery that mutations in the Cu/Zn superoxide dismutase (SOD1) gene affect approximately 20% of patients with familial ALS. Experiments using both transgenic...
متن کاملManagement of dysphagia in Parkinson's disease and amyotrophic lateral sclerosis.
PURPOSE To describe swallowing management in patients with amyotrophic lateral sclerosis (ALS) and Parkinson' disease (PD), to investigate whether physiopathology determines the choice of therapeutic approaches, and to investigate whether the disease duration modifies the therapeutic approaches. METHODS This is a long-term study comprising 24 patients with idiopathic PD and 27 patients with A...
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ژورنال
عنوان ژورنال: Brain
سال: 2000
ISSN: 1460-2156,0006-8950
DOI: 10.1093/brain/123.1.125